1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
Piroctone Oleamine
CAS: 68890-66-4
Molecular Formula: C16H30N2O3
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Names and Identifiers
| Name | Piroctone Oleamine |
| Synonyms | Octopirox octopiroxolamine piroctone olamine Piroctone Oleamine Pyridine-amino ethanol Hydroxyl pyrazole ketones 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine 4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon 1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt |
| CAS | 68890-66-4 |
| EINECS | 272-574-2 |
| InChI | InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2 |
| InChIKey | BTSZTGGZJQFALU-UHFFFAOYSA-N |
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Physico-chemical Properties
| Molecular Formula | C16H30N2O3 |
| Molar Mass | 298.43 |
| Density | 1.1[at 20℃] |
| Melting Point | 134.0 to 138.0 °C |
| Boling Point | 135-235℃[at 101 325 Pa] |
| Flash Point | 161.9°C |
| Water Solubility | 400-50000mg/L at 20-25℃ |
| Solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
| Vapor Presure | 0-0Pa at 20-25℃ |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,7502 |
| pKa | 5.9-7.4[at 20 ℃] |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD01690792 |
| In vitro study | Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL). |
| In vivo study | This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05). |
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Risk and Safety
| WGK Germany | 2 |
| RTECS | UU7786150 |
| HS Code | 2933399090 |
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Reference Information
| LogP | 1.05-3.86 at 20-25℃ |
| Introduction | the unique properties of pirrocone ethanolamine salt are mainly manifested in: 1. The anti-dandruff and anti-itching effect is better than that of similar products. 2. The dissolution performance and compounding performance are excellent, and the precipitation or stratification phenomenon will not occur when mixed with the raw materials of cosmetics. 3. Unique anti-dandruff mechanism, very low irritation, will not cause hair loss, hair loss, safety is better than similar anti-dandruff and anti-itching products. |
| Use | oxycodone is an efficient, non-toxic and non-irritating anti-dandruff agent, which can be widely used in anti-dandruff shampoo, hair liquid and hair conditioner and other care cosmetics. |
| biological activity | Piroctone olamin is a pyridine derivative. Has a fungicidal effect. |
| Target | specific |
Last Update：2024-04-09 21:21:28
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